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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-Cucurbitacin I
Cucurbitacin I

Chemical Structure : Cucurbitacin I

CAS No.: 2222-07-3

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Cucurbitacin I (JSI-124;JSI124;NSC 521777)

货号: PC-60456Not For Human Use, Lab Use Only.

Cucurbitacin I (JSI-124) is a triterpenoid compound that potently and selectively inhibits JAK/STAT3 pathway, suppresses the levels of phosphotyrosine STAT3 in A549 cell with IC50 of 500 nM.

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2 mg ￥1980 In stock
5 mg ￥3280 In stock
10 mg ￥5280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Cucurbitacin I (JSI-124) is a triterpenoid compound that potently and selectively inhibits JAK/STAT3 pathway, suppresses the levels of phosphotyrosine STAT3 in A549 cell with IC50 of 500 nM.
Cucurbitacin I shows high selectivity for JAK/STAT3 and does not inhibit other oncogenic and tumor survival pathways such as Akt, ERK1/2, JNK.
Cucurbitacin I inhibits STAT3 DNA binding and STAT3-mediated gene transcription, also decreases the levels of tyrosine-phosphorylated JAK but not Src.
Cucurbitacin I also inhibits Rac1 activation in breast cancer cells.

物理化学性质&存储条件

分子量 514.7
分子式 C30H42O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(10α)-2,16α,20,25-tetrahydroxy-9β-methyl-19-norlanosta-1,5,23E-triene-3,11,22-trione

参考文献

1. Blaskovich MA, et al. Cancer Res. 2003 Mar 15;63(6):1270-9.

2. Witkowski A, et al. Biochem Pharmacol. 1984 Apr 1;33(7):995-1004.

3. Nefedova Y, et al. Cancer Res. 2005 Oct 15;65(20):9525-35.

4. Lopez-Haber C, et al. Mol Pharmacol. 2013 May;83(5):1141-54.

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