W2014-S

Chemical Structure : W2014-S

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货号: PC-20627Not For Human Use, Lab Use Only.

W2014-S is a small molecule STAT3 inhibitor with binding Kd of 3.64 uM, disrupts STAT3 dimerization and selectively inhibits STAT3 signaling.

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1 g		Get quote

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生物&药学活性

W2014-S is a small molecule STAT3 inhibitor with binding Kd of 3.64 uM, disrupts STAT3 dimerization and selectively inhibits STAT3 signaling.
W2014-S inhibitsthe cell proliferation dose-dependently with IC50 values of 0.89 μM and 2.42 μM in A549 cell line, and of 2.36 μM and 2.66 μM in PC-9 cell line, respectively.
W2014-S significantly suppressed the colony formation at as low as 0.3 μM concentration in A549 and PC-9 cell lines in colony survival assay.
W2014-S (i.p. 5 or 15 mg/kg/day) inhibited the growth of human lung cancer cell xenografts and PDX models in vivo.

物理化学性质&存储条件

分子量	496.61
分子式	C30H32N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(N1CC=C(C2=CC=C3C(N=C(C4=CC=C(O[C@H](C5=CC=CC=C5)C)C=C4)N3)=N2)CC1)OC(C)(C)C

参考文献

1. Qiyao Zheng, et al. Theranostics. 2021 Jan 1;11(2):824-840.

W2014-S

生物&药学活性

物理化学性质&存储条件

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W2014-S

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物理化学性质&存储条件

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