STAT3 inhibitor DG-4

Chemical Structure : STAT3 inhibitor DG-4

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货号: PC-20605Not For Human Use, Lab Use Only.

DG-4 is a potent, selective inhibitor of STAT3-dependent transcription with IC50 of 0.12 uM in IL6-STAT3 luciferase reporter assays, 44-fold selectivity over IFN-γ STAT1.

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1 g		Get quote

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生物&药学活性

DG-4 is a potent, selective inhibitor of STAT3-dependent transcription with IC50 of 0.12 uM in IL6-STAT3 luciferase reporter assays, 44-fold selectivity over IFN-γ STAT1.
DG-4 does not bind to cellular STAT3 but to another prominent anticancer drug target, TrxR1.
DG-4 inhibits TrxR1 activity and contribute to TrxR1 inhibitory effects in cells at 1 uM.
DG-4 induces oxidative stress leading to Prx2/STAT3 oxidation, subsequently blocks STAT3-dependent transcription and induces cell death.

物理化学性质&存储条件

分子量	395.28
分子式	C18H20Cl2N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(NCCN1CCCCC1)C2=CC=C(N3C(C(Cl)=C(Cl)C=N3)=O)C=C2

参考文献

1. S Busker, et al. Sci Adv. 2020 Mar 20;6(12):eaax7945.