SOST inhibitor S6

Chemical Structure : SOST inhibitor S6

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货号: PC-49596Not For Human Use, Lab Use Only.

SOST inhibitor S6 is a small-molecule targeting Sclerostin (SOST), blocks STAT3 binding to SOST, inhibits breast cancer bone metastasis.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SOST inhibitor S6 is a small-molecule targeting Sclerostin (SOST), blocks STAT3 binding to SOST, inhibits breast cancer bone metastasis.
S6 treatment significantly inhibited the proliferation of SCP2 cells with an IC50 of 1.8 uM.
SOST inhibitor S6 significantly decreased STAT3 phosphorylation and TGF-β, KRAS, SMAD3 and CXCR4 expression in SCP2 cells.
S6 inhibited STAT3 phosphorylation and attenuated the downstream TGF-β/KRAS signaling pathways, which in turn inhibited breast cancer progression.
S6 treatment enhanced the differentiation of BMSCs, S6 (10 mg/kg) inhibited the destruction of bone cortex and reduced osteoclast activity in the tumor-bearing mice.

物理化学性质&存储条件

分子量	520.611
分子式	C29H24N6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((1H-benzo[d]imidazol-2-yl)methyl)-2-methyl-5-(4-(phenylamino)phthalazin-1-yl)benzenesulfonamide

参考文献

1. Lisha Sun, et al. Mol Cancer. 2022 Dec 29;21(1):228.