DR-1-55 | STAT3 inhibitor | Probechem Biochemicals

Chemical Structure : DR-1-55

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DR-1-55 (DR-155)

货号: PC-49434Not For Human Use, Lab Use Only.

DR-1-55 (DR-155) is a selective STAT3 inhibitor that covalently modifies a cysteine in the SH2 domain of STAT3.

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生物&药学活性

DR-1-55 (DR-155) is a selective STAT3 inhibitor that covalently modifies a cysteine in the SH2 domain of STAT3.
DR-1-55 reduced the expression of the STAT3 target gene MMP2, also reduced expression of ERBB2 and ERBB3 in devil facial tumor disease (DFTD) cells.
DR-1-55 (10 mg/kg) reduced tumor growth without observed toxicity in xenograft model of DFTD tumor, reduction of pY STAT3 (Figures 5D and 5E) and reduced MMP2 expression, increased the expression of B2M, while STAT3 expression was decreased.

物理化学性质&存储条件

分子量	806.672
分子式	C36H28F10N2O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(N-(4-cycloheptylbenzyl)-2-((2,3,4,5,6-pentafluoro-N-((perfluorophenyl)methyl)phenyl)sulfonamido)acetamido)-2-hydroxybenzoic acid

参考文献

1. Lindsay Kosack, et al. Cancer Cell. 2019 Jan 14;35(1):125-139.e9.

DR-1-55 (DR-155)

生物&药学活性

物理化学性质&存储条件

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DR-1-55 (DR-155)

生物&药学活性

物理化学性质&存储条件

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