BP-1-108

Chemical Structure : BP-1-108

加入收藏

货号: PC-20631Not For Human Use, Lab Use Only.

BP-1-108 is a small molecule STAT5-SH2 domain inhibitor with Ki of 2.8 uM, shows weak affinity for Stat1 and Stat3 (Ki, 9,7 and 8.0 uM respectively).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

BP-1-108 is a small molecule STAT5-SH2 domain inhibitor with Ki of 2.8 uM, shows weak affinity for Stat1 and Stat3 (Ki, 9,7 and 8.0 uM respectively).
BP-1-108 shows potent induction of apoptosis (IC50=20 μM), which correlated with potent and selective suppression of STAT5 phosphorylation, as well as inhibition of STAT5 target genes cyclin D1, cyclin D2, C-MYC, and MCL-1, in K562 and MV-4-11 human leukemia cells.
BP-1-108 shows negligible cytotoxic effects in normal bone marrow cells not expressing activated STAT5 protein.

物理化学性质&存储条件

分子量	578.72
分子式	C32H38N2O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(=O)(C4=C(C)C=C(C)C=C4C)=O)=O)C=C1O

参考文献

1. Brent D G Page, et al. J Med Chem. 2012 Feb 9;55(3):1047-55.

BP-1-108

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

BP-1-108

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.