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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-S3I-201
S3I-201

Chemical Structure : S3I-201

CAS No.: 501919-59-1

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S3I-201 (NSC 74859)

货号: PC-20465Not For Human Use, Lab Use Only.

S3I-201 (NSC 74859) is a selective chemical probe inhibitor of Stat3 activity, inhibits Stat3 DNA-binding activity in vitro with IC50 of 86 uM.

规格 价格 库存 数量
10 mg ￥580 In stock
25 mg ￥980 In stock
50 mg ￥1580 In stock
100 mg ￥2580 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

S3I-201 (NSC 74859) is a selective chemical probe inhibitor of Stat3 activity, inhibits Stat3 DNA-binding activity in vitro with IC50 of 86 uM.
S3I-201 preferentially inhibits Stat3 DNA-binding activity over that of Stat1 and Stat5 (IC50, >300 and 166 uM respectively).
S3I-201 disrupts Stat3·Stat3 complex formation in vitro and in intact cells.
S3I-201 suppresses Stat3-dependent but not Stat3-independent transcriptional activity.
S3I-201 inhibits anchorage-dependent and -independent growth only of cells that contain persistently active Stat3.
S3I-201 (30 uM) inhibits cyclin D1, Bcl-xL, and survivin expression and induces apoptosis in a Stat3-dependent manner in breast carcinoma MDA-MB-435 cell line.
S3I-201 (5 mg/kg, i.v.) induces tumor regression in human breast (MDA-MB-231) tumor-bearing mice.

物理化学性质&存储条件

分子量 365.36
分子式 C16H15NO7S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzoic acid, 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-

参考文献

1. Lin L, et al. Oncogene. 2009 Feb 19;28(7):961-72.

2. Siddiquee K, et al. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7391-6.

3. Pang M, et al. Kidney Int. 2010 Aug;78(3):257-68.

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