| Cat. No. |
Product Name |
Information |
| PC-27569 |
WHZ-04
Pf20S inhibitor
|
WHZ-04 is a potent, selective P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 20.8 nM for Pf20S β5, has 68-fold and 4.8-fold selectivity over β5c and β5i, shows antimalarial EC50 of 8.4 nM against Pf 3D7. |
| PC-27443 |
RUPB-61
PfPKG inhibitor
|
RUPB-61 is a potent, selective and orally bioavailable inhibitor of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) with IC50 of 13 nM, EC50 of 50 uM against multi-drug resistant P. falciparum lab strain 3D7, blocks sporozoite infection of the liver. |
| PC-27209 |
CWHM-1008
Antimalarial
|
CWHM-1008 is a potent, orally efficacious antimalarial agent with EC50 values of 46 nM and 21 nM against drug sensitive Plasmodium falciparum 3D7 and drug resistant Dd2 strains, respectively. |
| PC-27175 |
UCB-9721
TgMyoA inhibitor
|
UCB-9721 is a potent inhibitor of T. gondii MyoA (TgMyoA) with IC50 of 31 nM, a class XIV myosin motor of apicomplexan parasites, inhibits TgMyoA actin-activated ATPase activity. |
| PC-26128 |
Cruzidione
T. cruzi inhibitor
|
Cruzidione is a potent anti-T. cruzi activity and anti-Chagas compound with anti-trypanosomal activity with IC50 of 3.65 uM. |
| PC-25293 |
LXE408
Kinetoplastid proteasome inhibitor
|
Galeflaprit (LXE408) is a potent, selective inhibitor of the kinetoplastid proteasome with IC50 of 0.04 uM (L. donovani proteasome), inhibits L. donovani amastigote proliferation within primary mouse macrophages (IC50=0.04 uM). |
| PC-25200 |
BKI-1708
CpCDPK1 inhibitor
|
BKI-1708 is a highly potent, specific Cryptosporidium calcium-dependent protein kinase 1 (CDPK1) inhibitor with IC50 of 0.7 nM (CpCDPK1, C. parvum CDPK1) and EC50 of 0.4 uM against C. parvum parasites in Nanoluciferase assays. |
| PC-25005 |
ZY-19489
Antimalarial
|
Sutidiazine (Zintrodiazine, ZY-19489, MMV 253, AZ-13721412) is a novel antimalarial triaminopyrimidine compound with IC50 of 9 nM against sexual blood stage of Plasmodium falciparum (Pf). |
| PC-24759 |
BKI-1748
CDPK1 inhibitor
|
BKI-1748 a small molecule bumped kinase inhibitor targeting calcium dependent protein kinase 1 (CDPK1), inhibits TgCDPK1 and NcCDPK1 enzyme activities at low nM-concentrations, inhibits proliferation of apicomplexan parasites with EC50 of 165 nM for N. caninum and 43 nM for T. gondii. |
| PC-23131 |
EDI048
Cryptosporidium PI4K inhibitor
|
EDI048 (EDI-048) is a specific, ATP-competitive, gastrointestinal-targeted Cryptosporidium PI(4)K (CpPI(4)K) inhibitor with IC50 of 4 nM, >300-fold with human orthologue HsPI(4)K, demonstrates in vitro anti-Cryptosporidium activity (Cp CPE, EC50=52 nM). |
| PC-22969 |
UCT594
Pf PI4K inhibitor
|
UCT594 is a highly potent, selective Plasmodium phosphatidylinositol 4-kinase (PI4K) inhibitor, inhibits the P. vivax PI4K enzyme with IC50 of 24 nM, >200-fold selective over human PI4Kβ ortholog. |
| PC-22800 |
SW584
Pf20Sβ5 inhibitor
|
SW584 is a potent, species-selective, orally active inhibitor of P. falciparum proteasome β5 active site (Pf20Sβ5) with IC50 of 5.8 nM, shows antimalarial activity with EC50 of 3 nM (Pf3D7 and PfDd2). |
