| Cat. No. |
Product Name |
Information |
| PC-45379 |
Mebendazole
|
Mebendazole is a highly effective, broad-spectrum antihelmintic by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubes in their intestinal cells.. |
| PC-45158 |
Doramectin
Antibiotic
|
Doramectin is a derivative of ivermectin that approved for the treatment of parasites, is an active compound against S.mansoni in an NMRI mouse infection model. |
| PC-25297 |
Fexinidazole
T. brucei inhibitor
|
Fexinidazole (HOE 239) is an orally active, potent nitroimidazole antitrypanosomal agent, shows trypanocidal activity against T. brucei subspecies and strains with IC50 of 0.7-3.3 uM, has the potential for human sleeping sickness (HAT) caused by infection with T. brucei. |
| PC-25293 |
LXE408
Kinetoplastid proteasome inhibitor
|
LXE408 is a potent, selective inhibitor of the kinetoplastid proteasome with IC50 of 0.04 uM (L. donovani proteasome), inhibits L. donovani amastigote proliferation within primary mouse macrophages (IC50=0.04 uM). |
| PC-25292 |
DNDI-VL-2098
Visceral leishmaniasis inhibitor
|
DNDI-VL-2098 is an orally effective preclinical drug candidate for visceral leishmaniasis (VL) with IC50 of 0.17 uM for L. infantum. |
| PC-25291 |
DNDI-0690
Visceral leishmaniasis inhibitor
|
DNDI-0690 is a clinical drug candidate for visceral leishmaniasis (VL), demonstrated excellent in vitro activity against three Old World and three New World cutaneous Leishmania strains (EC50<5 uM). |
| PC-25290 |
DNDI-5561
T. cruzi inhibitor
|
DNDI-5561 is a small molecule inhibitor of T. cruzi and L. infantum with IC50 of 38 uM and 0.2 uM. |
| PC-25202 |
BKI-1841
CpCDPK1 inhibitor
|
BKI-1841 is a highly potent, specific Cryptosporidium calcium-dependent protein kinase 1 (CDPK1) inhibitor with IC50 of 3 nM (CpCDPK1, C. parvum CDPK1) and EC50 of 0.7 uM against C. parvum parasites in Nanoluciferase assays. |
| PC-25201 |
BKI-1770
CpCDPK1 inhibitor
|
BKI-1770 is a highly potent, specific Cryptosporidium calcium-dependent protein kinase 1 (CDPK1) inhibitor with IC50 of 2 nM (CpCDPK1, C. parvum CDPK1) and EC50 of 0.5 uM against C. parvum parasites in Nanoluciferase assays. |
| PC-25200 |
BKI-1708
CpCDPK1 inhibitor
|
BKI-1708 is a highly potent, specific Cryptosporidium calcium-dependent protein kinase 1 (CDPK1) inhibitor with IC50 of 0.7 nM (CpCDPK1, C. parvum CDPK1) and EC50 of 0.4 uM against C. parvum parasites in Nanoluciferase assays. |
| PC-25134 |
T231
Antimalarial
|
T231 is the prodrug of T111, a potent acridone antimalarial inhibitor against blood, liver, and mosquito stages of malaria parasite. |
| PC-25133 |
T111
Antimalarial
|
T111 is a potent acridone antimalarial inhibitor against blood, liver, and mosquito stages of malaria parasite, inhibits mitochondrial electron transport chain, has IC50 of 0.028, 0.11 and 0.11 nM for P. falciparum strains Dd2, DR1, and DR4. |
