GNF-Pf-5660 |CAS:421572-88-5 Probechem Biochemicals

Chemical Structure : GNF-Pf-5660

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GNF-Pf-5660 (GNF-Pf 5660)

货号: PC-61006Not For Human Use, Lab Use Only.

GNF-Pf-5660 is an antimalarial candidate that demonstrates potent blood-stage and transmission-blocking activity, shows potent ABS activity (IC50 <25 nM) against drug-sensitive 3D7 and multidrug-resistant Dd2 parasites.

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生物&药学活性

GNF-Pf-5660 is an antimalarial candidate that demonstrates potent blood-stage and transmission-blocking activity, shows potent ABS activity (IC50 <25 nM) against drug-sensitive 3D7 and multidrug-resistant Dd2 parasites.
The digestive vacuole membrane-spanning transporter PfMDR1 is a determinant of parasite resistance to GNF-Pf-5660.

物理化学性质&存储条件

分子量	481.973
分子式	C27H28ClNO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 4-(2-chlorophenyl)-7-(3,4-dimethoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

参考文献

1. Vanaerschot M, et al. Nat Microbiol. 2017 Oct;2(10):1403-1414.

GNF-Pf-5660 (GNF-Pf 5660)

生物&药学活性

物理化学性质&存储条件

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GNF-Pf-5660 (GNF-Pf 5660)

生物&药学活性

物理化学性质&存储条件

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