| Cat. No. |
Product Name |
Information |
| PC-23893 |
PRC1590
P.falciparum inhibitor
|
PRC1590 is a tetrahydro-β-carboline compound that potently kills the malaria parasite with EC50 of 145 nM and 142 nM in growth inhibition assays in 3D7WT and Dd2 strains. |
| PC-23720 |
DSM705 hydrochloride
DHODH inhibitor
|
DSM705 hydrochloride (DSM 705) is a potent, highly selective, long-duration and orally bioavailable malaria DHODH inhibitor with IC50 of 95 nM (PfDHODH), and 52 nM (P. vivax DHODH). |
| PC-23718 |
Cruzipain inhibitor SH-1
Cruzipain inhibitor
|
Cruzipain inhibitor SH-1 is a potent, selective and covalent cysteine protease Cruzipain (CZP) of Trypanosoma cruzi with IC50 of 28 nM, without inhibition on human cathepsin L. |
| PC-23717 |
DSM1465
PfDHODH inhibitor
|
DSM1465 is a potent, selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with IC50 of 15 nM, inhibits P. falciparum 3D7 (Pf3D7) parasites in whole-cell assays with EC50 of 1.4 nM. |
| PC-23705 |
TKK129
Antimalarial
|
TKK129 is a 3-hydroxypropanamidine antimalarial inhibitor of IC50 of 2 nM (Pf3D7), shows excellent antiplasmodial in vitro activity against drug-sensitive and -resistant Plasmodium falciparum strains (IC50=6-16 nM). |
| PC-23704 |
TKK130
Antimalarial
|
TKK130 is a 3-hydroxypropanamidine antimalarial inhibitor of IC50 of 2 nM (Pf3D7), inhibits synthetic hemozoin (β-hematin) formation, shows excellent antiplasmodial in vitro activity against drug-sensitive and -resistant Plasmodium falciparum strains (IC50=2-12 nM). |
| PC-23695 |
SLU-10906
CpPDE1 inhibitor
|
SLU-10906 is a potent inhibitor of parasite Cryptosporidium with EC50 of 0.19 uM (Cp HCT-8 assay), selectively targets parasite phosphodiesterase CpPDE1. |
| PC-23663 |
MMV009108
PfNCR1 inhibitor
|
MMV009108 is a small molecule inhibitor of P. falciparum Niemann-Pick type C1-related (PfNCR1) transporter, hypersensitizes parasites to saponin. |
| PC-23658 |
SAL-0010042
P. falciparum PDEβ inhibitor
|
SAL-0010042 is a fast-acting and potent Plasmodium falciparum PDEβ inhibitor with IC50 of 10.8 nM for cGMP hydrolysis in crude gametocyte membrane preparations, and EC50 of 142 nM for 3D7 blood stage. |
| PC-23657 |
SAL-0010003
P. falciparum PDEβ inhibitor
|
SAL-0010003 is a fast-acting and potent Plasmodium falciparum PDEβ inhibitor with IC50 of 17.3 nM for cGMP hydrolysis in crude gametocyte membrane preparations, and EC50 of 327 nM for 3D7 blood stage. |
| PC-23626 |
TCDMC-143160
TcTDH inhibitor
|
TCDMC-143160 is a specific inhibitor of T. cruzi L-threonine dehydrogrenase (TcTDH) with IC50 of 3.5 uM, inhibits the threonine degradation pathway and interferes with parasite growth and viability. |
| PC-23600 |
ML901
PfYRS inhibitor
|
ML901 is a potent, specific inhibitor of P. falciparum tyrosine tRNA synthetase (PfYRS, PfTyrRS), shows potent activity against P. falciparum with IC50 of 2.0 nM. |
