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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-TDI6245
TDI6245

Chemical Structure : TDI6245

CAS No.:

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TDI6245 (TDI-6245)

货号: PC-27565Not For Human Use, Lab Use Only.

TDI6245 (TDI-6245) is a highly potent Plasmodium 20S proteasome core (Pf20S) β5 inhibitor with IC50 of 110 nM, shows potent anti-Pf 3D7 activity with EC50 of 38 nM, has >60 fold selectivity over human c-20S β5c and human i-20S β5i.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TDI6245 (TDI-6245) is a highly potent Plasmodium 20S proteasome core (Pf20S) β5 inhibitor with IC50 of 110 nM, shows potent anti-Pf 3D7 activity with EC50 of 38 nM, has >60 fold selectivity over human c-20S β5c and human i-20S β5i.

物理化学性质&存储条件

分子量 500.61
分子式 C25H32N4O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N4-(tert-butyl)-2-((4-methylphenyl)sulfonamido)-N1-(2-(1-oxoisoindolin-2-yl)ethyl)succinamide

参考文献

1. Hao Zhang, et al. ACS Omega. 2026 Jul 21;11(30):45549-45559.

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