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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-MPI-5
MPI-5

Chemical Structure : MPI-5

CAS No.: 2817715-32-3

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MPI-5

货号: PC-27567Not For Human Use, Lab Use Only.

MPI-5 is a potent, covalent, reversible P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 2 nM, 85 nM and 24 nM for Pf20S β5, Hs20S β5c and Hs20S β5i respectively, exhibits fast-acting antimalarial activity with LD50 of 21 nM for Pf 3D7 strain.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MPI-5 is a potent, covalent, reversible P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 2 nM, 85 nM and 24 nM for Pf20S β5, Hs20S β5c and Hs20S β5i respectively, exhibits fast-acting antimalarial activity with LD50 of 21 nM for Pf 3D7 strain.

物理化学性质&存储条件

分子量 352.24
分子式 C20H25BN2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

((R)-2-([1,1'-biphenyl]-4-yl)-1-((R)-1-methylpyrrolidine-2-carboxamido)ethyl)boronic acid

参考文献

1. Stanley C Xie, et al. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2107213118.

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