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Closantel

Chemical Structure : Closantel

CAS No.: 57808-65-8

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Closantel (FICD inhibitor C22)

货号: PC-45380Not For Human Use, Lab Use Only.

Closantel (FICD inhibitor C22) is a veterinary anthelmintic with known proton ionophore activities, also is a small molecule inhibitor of the AMP transferase FICD with IC50 of 7.27 uM.

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250 mg ￥880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Closantel (FICD inhibitor C22) is a veterinary anthelmintic with known proton ionophore activities, also is a small molecule inhibitor of the AMP transferase FICD with IC50 of 7.27 uM.
Closantel (FICD inhibitor C22) is identified as a potent and specific inhibitor of filarial chitinases; also shows to be an allosteric inhibitor of SPAK and OSR1.
FICD inhibitor C22 is a small molecule inhibitor of the AMP transferase FICD with IC50 of 7.27 uM, significantly inhibits FICD-mediated BiP/GRP78 AMPylation in intact cells, while only weakly inhibiting BiP/GRP78 deAMPylation.
FICD inhibitor C22 also efficiently inhibit pathogenic FICD variants and improve proinsulin processing in β cells.
FICD is a bi-functional enzyme, catalyzing both AMP addition (AMPylation) and removal (deAMPylation) from the ER resident chaperone BiP/GRP78.

物理化学性质&存储条件

分子量 663.0737
分子式 C22H14Cl2I2N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 49 mg/mL
Chemical Name/SMILES

Benzamide, N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodo-

参考文献

1. AlAmri MA, et al. ChemMedChem. 2017 May 9;12(9):639-645.

2. Gloeckner C, et al. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3424-9.

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