Ganaplacide (KAF156, GNF-156)

Chemical Structure : Ganaplacide

CAS No.: 1261113-96-5

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货号: PC-61378Not For Human Use, Lab Use Only.

Ganaplacide (KAF156, GNF-156) is a novel antimalarial clinical candidate that shows blood schizonticidal activity with IC50 of 6-17.4 nM against P falciparum drug-sensitive and drug-resistant strains.

规格	价格	库存
5 mg	￥3980	In stock
10 mg	￥5880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Ganaplacide (KAF156, GNF-156) is a novel antimalarial clinical candidate that shows blood schizonticidal activity with IC50 of 6-17.4 nM against P falciparum drug-sensitive and drug-resistant strains.
KAF156 demonstrates potent therapeutic activity in mouse models of malaria with 50, 90, and 99% effective doses of 0.6, 0.9, and 1.4 mg/kg, respectively.
KAF156 is completely protective as a single oral dose of 10 mg/kg in sporozoite challenge mouse model.
KAF156 shows the potential to treat, prevent, and block the transmission of malaria.

物理化学性质&存储条件

分子量	411.457
分子式	C22H23F2N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-amino-1-[3-(4-fluoroanilino)-2-(4-fluorophenyl)-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]ethan-1-one

参考文献

1. Kuhen KL, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5060-7.

2. Leong FJ, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6437-43.

3. Lim MY, et al. Nat Microbiol. 2016 Sep 19:16166.

4. White NJ, et al. N Engl J Med. 2016 Sep 22;375(12):1152-60.