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Pyrimethamine

Chemical Structure : Pyrimethamine

CAS No.: 58-14-0

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Pyrimethamine (Pirimecidan;Pirimetamin;RP 4753)

货号: PC-45409Not For Human Use, Lab Use Only.

Pyrimethamine is a synthetic derivative of ethyl-pyrimidine with potent antimalarial properties, interferes with the regeneration of tetrahydrofolic acid from dihydrofolate by competitively inhibiting DHFR, has also been found to reduce the expression of SOD1.

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100 mg ￥1280 In stock
500 mg ￥2980 In stock
1 g ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Pyrimethamine is a synthetic derivative of ethyl-pyrimidine with potent antimalarial properties, interferes with the regeneration of tetrahydrofolic acid from dihydrofolate by competitively inhibiting DHFR, has also been found to reduce the expression of SOD1.

物理化学性质&存储条件

分子量 248.7114
分子式 C12H13ClN4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-

参考文献

1. Lange DJ, et al. Amyotroph Lateral Scler Frontotemporal Degener. 2013 Apr;14(3):199-204.

2. Wright PD, et al. Neurosci Lett. 2010 Oct 4;482(3):188-92.

3. Martins-Duarte ÉS, et al. Exp Parasitol. 2013 Mar;133(3):294-9.

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