DSM265 | PfDHODH inhibitor | Probechem Biochemicals

Chemical Structure : DSM265

CAS No.: 1282041-94-4

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DSM265 (DSM-265;DSM 265)

货号: PC-60458Not For Human Use, Lab Use Only.

DSM265 is a potent, highly selective, long-duration and orally bioavailable malaria DHODH (PfDHODH) inhibitor with IC50 of 0.01 ug/mL.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

DSM265 is a potent, highly selective, long-duration and orally bioavailable malaria DHODH (PfDHODH) inhibitor with IC50 of 0.01 ug/mL.
DSM265 displays excellent selectivity versus human DHODH.
DSM265 potently kills both sensitive and drug resistant strains of the parasite with EC50 of 0.001-0.004 ug/ml.
DSM265 has favorable pharmacokinetic properties and efficacious against both blood and liver stages of P. falciparum in vivo.

物理化学性质&存储条件

分子量	415.334
分子式	C14H12F7N5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1,1-Difluoroethyl)-5-methyl-N-[4-(pentafluoro-λ6-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

参考文献

1. Coteron JM, et al. J Med Chem. 2011 Aug 11;54(15):5540-61.

2. Phillips MA, et al. Sci Transl Med. 2015 Jul 15;7(296):296ra111.

3. Kokkonda S, et al. J Med Chem. 2016 Jun 9;59(11):5416-31.

4. Phillips MA, et al. ACS Infect Dis. 2016 Dec 9;2(12):945-957.

DSM265 (DSM-265;DSM 265)

生物&药学活性

物理化学性质&存储条件

参考文献

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DSM265 (DSM-265;DSM 265)

生物&药学活性

物理化学性质&存储条件

参考文献

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