IID432 (IID-432)

Chemical Structure : IID432

CAS No.: 3094992-69-2

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货号: PC-25928Not For Human Use, Lab Use Only.

IID432 (IID-432) is a highly potent inhibitor of Trypanosoma cruzi topoisomerase II (T. cruzi Topo II), shows potent activity against T. cruzi with EC50 of 8 nM.

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10 mg	￥3980	In stock
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生物&药学活性

IID432 (IID-432) is a highly potent, covalent inhibitor of Trypanosoma cruzi topoisomerase II (T. cruzi Topo II), shows potent activity against T. cruzi with EC50 of 8 nM.

IID432 shows covalently engaging a parasite-specific cysteine (Cys477), thereby conferring selectivity over the human TOP2A.

IID432 displays favorable oral pharmacokinetics, with no off-target activity on human topoisomerases.

IID432 rapidly induces parasite-specific DNA damage and produces sterilizing activity in vitro and in vivo without recrudescence.

物理化学性质&存储条件

分子量	361.41
分子式	C19H19N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(3-cyano-1H-1,2,4-triazol-1-yl)-N-(1-(2-methylquinolin-6-yl)pyrrolidin-3-yl)acetamide

参考文献

1. René O, et al. J Med Chem. 2026 Jan 7. doi: 10.1021/acs.jmedchem.5c02459.

IID432 (IID-432)

生物&药学活性

物理化学性质&存储条件

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IID432 (IID-432)

生物&药学活性

物理化学性质&存储条件

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