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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-CWHM-1008
CWHM-1008

Chemical Structure : CWHM-1008

CAS No.: 2362539-97-5

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CWHM-1008 (CWHM1008)

货号: PC-27209Not For Human Use, Lab Use Only.

CWHM-1008 is a potent, orally efficacious antimalarial agent with EC50 values of 46 nM and 21 nM against drug sensitive Plasmodium falciparum 3D7 and drug resistant Dd2 strains, respectively.

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5 mg ￥2280 In stock
10 mg ￥3780 In stock
25 mg ￥5780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CWHM-1008 is a potent, orally efficacious antimalarial agent with EC50 values of 46 nM and 21 nM against drug sensitive Plasmodium falciparum 3D7 and drug resistant Dd2 strains, respectively.
CWHM-1008 has equivalent potency to chloroquine (CQ) in the Pf 3D7 strain and 10-fold greater potency than CQ against the multi-drug resistant Dd2 (IC50 = 21 ± 1 nM vs. CQ IC50 = 196 ± 14 nM).
CWHM-1008 does not inhibit plasmepsins II, IV, V, IX or X.
CWHM-1008 is orally efficacious in a mouse model of malaria (q.d.; ED99 ~ 30 mg/kg/day).
CWHM-1008 also induces apoptosis and protective autophagy through the Akt/mTOR axis on lung adenocarcinoma (LUAD) cells, inhibits the growth and induces apoptosis of A549 cell in nude mice in vivo.

物理化学性质&存储条件

分子量 405.47
分子式 C22H26F3N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3R,4S)-N-((S)-1-(4-(dimethylamino)phenyl)ethyl)-4-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide

参考文献

1. Meyers MJ, et al. J Med Chem. 2019 Apr 11;62(7):3503-3512.

2. Zhang J, et al. J Oncol. 2021 Sep 11;2021:5548128.

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