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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-BKI-1708
BKI-1708

Chemical Structure : BKI-1708

CAS No.: 2332840-70-5

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BKI-1708 (BKI 1708)

货号: PC-25200Not For Human Use, Lab Use Only.

BKI-1708 is a highly potent, specific Cryptosporidium calcium-dependent protein kinase 1 (CDPK1) inhibitor with IC50 of 0.7 nM (CpCDPK1, C. parvum CDPK1) and EC50 of 0.4 uM against C. parvum parasites in Nanoluciferase assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BKI-1708 is a highly potent, specific Cryptosporidium calcium-dependent protein kinase 1 (CDPK1) inhibitor with IC50 of 0.7 nM (CpCDPK1, C. parvum CDPK1) and EC50 of 0.4 uM against C. parvum parasites in Nanoluciferase assays.
BKI-1708 is active against C. parvum and C. hominis parasites with EC50 of 0.05-0.2 uM.
BKI-1708 (8 mg/kg QD, oral) exhibited efficacy in a mouse model of Cryptosporidium infection.

物理化学性质&存储条件

分子量 394.48
分子式 C22H26N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-amino-3-(6-cyclopropoxynaphthalen-2-yl)-1-(3-hydroxy-2,2-dimethylpropyl)-1H-pyrazole-4-carboxamide

参考文献

1. Hulverson MA, et al. Antimicrob Agents Chemother. 2023 Apr 18;67(4):e0142522.

2. Choi R, et al. PLoS Negl Trop Dis. 2025 Jul 30;19(7):e0013263.

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