WHZ-04 | Pf20S inhibitor | Probechem Biochemicals

Chemical Structure : WHZ-04

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WHZ-04 (WHZ04)

货号: PC-27569Not For Human Use, Lab Use Only.

WHZ-04 is a potent, selective P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 20.8 nM for Pf20S β5, has 68-fold and 4.8-fold selectivity over β5c and β5i, shows antimalarial EC50 of 8.4 nM against Pf 3D7.

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生物&药学活性

WHZ-04 is a potent, selective P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 20.8 nM for Pf20S β5, has 68-fold and 4.8-fold selectivity over β5c and β5i, shows antimalarial EC50 of 8.4 nM against Pf 3D7.

物理化学性质&存储条件

分子量	488.60
分子式	C24H32N4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N1-(2-benzamidoethyl)-N4-(tert-butyl)-2-((4-methylphenyl)sulfonamido)succinamide

参考文献

1. Wenhu Zhan, et al. J Med Chem. 2019 Jul 11;62(13):6137-6145.

WHZ-04 (WHZ04)

生物&药学活性

物理化学性质&存储条件

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WHZ-04 (WHZ04)

生物&药学活性

物理化学性质&存储条件

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