| Cat. No. |
Product Name |
Information |
| PC-42679 |
Rucaparib phosphate
PARP inhibitor
|
Rucaparib (AG014699, PF 01367338) phosphate is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains. |
| PC-42410 |
Olaparib
PARP inhibitor
|
Olaparib (AZD2281, KU-0059436) is a potent, specific, and orally active PARP inhibitor with IC50 of 5 and 1 nM for PARP1 and PARP2, respectively. |
| PC-45620 |
MN-64
TNKS1 inhibitor
|
MN-64 is a potent and selective inhibitor of Tankyrase 1 (TNKS1) with IC50 of 6 nM. |
| PC-45571 |
NMS-P118
PARP1 inhibitor
|
NMS-P118 is a potent and highly selective PARP-1 inhibitor with Kd of 9 nM; shows 150-fold selectivity for PARP-1 over PARP-2. |
| PC-42269 |
BGP-15
PARP inhibitor, Hsp72 modulator
|
BGP-15 is a PARP inhibitor and an inducer of HSF-1/HSP72 (cotreatment with heat) in vtiro, has no effect on HSP90 levels. |
| PC-45086 |
WIKI4
TNKS2 inhibitor, Wnt/β-catenin inhibitor
|
WIKI4 is a novel small molecule inhibitor of the Wnt/β-catenin pathway by inhibiting the enzymatic activity of TNKS2. |
| PC-42683 |
Niraparib tosylate
PARP1/2 inhibitor
|
Niraparib tosylate (MK-4827) is a highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2. |
| PC-42682 |
MK-4827 hydrochloride
PARP1/2 inhibitor
|
Niraparib (MK-4827) hydrochloride is a highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2. |
| PC-42681 |
Niraparib
PARP inhibitor
|
Niraparib (MK-4827, MK4827) is a highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2. |
| PC-42678 |
A-966492
PARP inhibitor
|
A-966492 (A966492) is a highly potent and efficacious PARP inhibitor with Ki/EC50 of 1 nM/1 nM for PARP-1. |
| PC-23463 |
UPF-1069
PARP-2 inhibitor
|
UPF-1069 is a potent, selective PARP-2 inhibitor with IC50 of 0.3 uM, >25-fold selective over PARP-1 (IC50= 8 uM). |
| PC-23199 |
K-756
TNKS1/2 inhibitor
|
K-756 is a small molecule inhibitor of the Wnt/β-catenin pathway with IC50 of 110 nM in Wnt/β-catenin reporter assay, and selective tankyrase (TNKS) inhibitor with IC50 of 31 and 36 nM for TNKS1 and TNKS2, stabilizes Axin1/2 by inhibiting TNKS1/2. |
