NMS-P118 |CAS:1262417-51-5 Probechem Biochemicals

Chemical Structure : NMS-P118

CAS No.: 1262417-51-5

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NMS-P118 (NMS-P 118)

货号: PC-45571Not For Human Use, Lab Use Only.

NMS-P118 is a potent and highly selective PARP-1 inhibitor with Kd of 9 nM; shows 150-fold selectivity for PARP-1 over PARP-2.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
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生物&药学活性

NMS-P118 is a potent and highly selective PARP-1 inhibitor with Kd of 9 nM; shows 150-fold selectivity for PARP-1 over PARP-2.
NMS-P118 exhibits excellent ADME and pharmacokinetic profiles and high efficacy in MDA-MB-436 and Capan-1 xenograft models; orally available.

物理化学性质&存储条件

分子量	395.4187
分子式	C20H24F3N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: 16 mg/mL
Chemical Name/SMILES	1H-Isoindole-4-carboxamide, 2-[1-(4,4-difluorocyclohexyl)-4-piperidinyl]-6-fluoro-2,3-dihydro-3-oxo-

参考文献

1. Papeo G, et al. J Med Chem. 2015 Sep 10;58(17):6875-98.

NMS-P118 (NMS-P 118)

生物&药学活性

物理化学性质&存储条件

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NMS-P118 (NMS-P 118)

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物理化学性质&存储条件

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