BGP-15 |CAS:66611-37-8 Probechem Biochemicals

Chemical Structure : BGP-15

CAS No.: 66611-37-8

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BGP-15 (BGP 15;BGP15)

货号: PC-42269Not For Human Use, Lab Use Only.

BGP-15 is a PARP inhibitor and an inducer of HSF-1/HSP72 (cotreatment with heat) in vtiro, has no effect on HSP90 levels.

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25 mg	￥1580	In stock
50 mg	￥2580	In stock
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生物&药学活性

BGP-15 is a PARP inhibitor and an inducer of HSF-1/HSP72 (cotreatment with heat) in vtiro, has no effect on HSP90 levels.
BGP-15 markedly increases the phosphorylation of HSF1 and expression of HSF1 and HSP72 in adipocytes and muscle cells.
BGP-15 protects against obesity-induced insulin resistance and orally active.
BGP-15 alleviates ventilation-induced diaphragm dysfunction associated with HSP72 induction and PARP-1 inhibition.

物理化学性质&存储条件

分子量	351.272
分子式	C14H24Cl2N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 11.33 mg/mL
Chemical Name/SMILES	3-Pyridinecarboximidamide, N-[2-hydroxy-3-(1-piperidinyl)propoxy]-, hydrochloride (1:2)

参考文献

1. Salah H, et al. Sci Transl Med. 2016 Aug 3;8(350):350ra103.

2. Chung J, et al. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1739-44.

3. Racz I, et al. Biochem Pharmacol. 2002 Mar 15;63(6):1099-111.

4. Kardon T, et al. Anticancer Res. 2006 Mar-Apr;26(2A):1023-8.

BGP-15 (BGP 15;BGP15)

生物&药学活性

物理化学性质&存储条件

参考文献

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BGP-15 (BGP 15;BGP15)

生物&药学活性

物理化学性质&存储条件

参考文献

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