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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-TNKS-IN-41
TNKS-IN-41

Chemical Structure : TNKS-IN-41

CAS No.: 1584646-59-2

TNKS-IN-41 (Tankyrase inhibitor 41)

货号: PC-60367Not For Human Use, Lab Use Only.

TNKS-IN-41 is a highly potent and selective tankyrase inhibitor with pIC50 of 8.5 and 8.1 for TNKS1 and TNKS2, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    TNKS-IN-41 is a highly potent and selective tankyrase inhibitor with pIC50 of 8.5 and 8.1 for TNKS1 and TNKS2, respectively.
    TNKS-IN-41 shows high selectivity over the other PARP family members.
    TNKS-IN-41 induces growth inhibition of a number of tumor derived cell lines.

    物理化学性质&存储条件

    分子量 482.508
    分子式 C24H22N10O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (1-Methyl-1H-pyrazol-3-yl)(4-(4-(tetrazolo[1,5-a]quinoxalin-4-ylamino)benzoyl)piperazin-1-yl)methanone

    参考文献

    1. Thomson DW, et al. J Med Chem. 2017 Jul 13;60(13):5455-5471.

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