| Cat. No. |
Product Name |
Information |
| PC-27880 |
YCH3292
PARP inhibitor
|
YCH3292 is a potent, new-generation antiresistant PARP inhibitor with IC50 of <0.001 nM for PARP1/2, exhibits robust antiproliferative activity against Capan-1/TP cells with IC50 of 0.23 nM, overcomes acquired resistance to PARPi. |
| PC-27879 |
YCH1899
PARP inhibitor
|
YCH1899 is a potent, new-generation antiresistant PARP inhibitor with IC50 of <0.001 nM for PARP1/2, exhibits antiproliferation activity against olaparib- and talazoparib-resistant cells with IC50 of 0.89 and 1.13 nM, respectively. |
| PC-27584 |
PARP7 inhibitor B-6
PARP7 inhibitor
|
PARP7 inhibitor B-6 is a potent, brain-penetrant PARP7 inhibitor with IC50 of 22.8 nM. |
| PC-26674 |
NU1025
PARP inhibitor
|
NU1025 is a potent PARP inhibitor with IC50 of 400 nM and Ki of 48 nM, potentiates the cytotoxicity of ionizing radiation and anticancer agents, shows anti-cancer and neuroprotective activity. |
| PC-26590 |
XW-17
PARP14 inhibitor
|
XW-17 is a highly potent, selective PARP14 inhibitor with IC50 of 3.03 nM. |
| PC-26332 |
Ivuparib
PARP inhibitor
|
Ivuparib is a potent poly (ADP-ribose) polymerase (PARP) inhibitor with antineoplastic activities. |
| PC-25988 |
ARCher-142
TNKS2 ARC4 inhibitor
|
ARCher-142 (S8/ARCher-142) is a specific TNKS2 ARC4 inhibitor that specifically targeting the ARC4 peptide binding domain, binds selectively to TNKS2 ARC4 with a potency of 8 uM, attenuates the WNT/β-catenin pathway in cells. |
| PC-25420 |
PARP15 inhibitor 7
PARP15 inhibitor
|
PARP15 inhibitor 7 is a selective inhibitor of mono-ART PARP15 with IC50 of 1.1 uM, inhibits PARP10 with IC50 of 2.4 uM, does not PARP2, TNKS2 and PARP14. |
| PC-25419 |
OUL245
PARP2 inhibitor
|
OUL245 is a potent, selective PARP2 inhibitor with IC50 of 44 nM, weakly inhibits multiple poly-ARTs at low μM concentration, does not inhibit mono-ARTs PARP7, PARP11, PARP12, PARP14, and PARP15. |
| PC-25418 |
OUL232
PARP10 inhibitor
|
OUL232 is a potent, selective inhibitor of mono-ARTs PARP7, PARP10, PARP11, PARP12, PARP14, and PARP15 with IC50 of 83 nM, 7.8 nM, 240 nM, 160 nM, 300 nM and 56 nM respectively. |
| PC-25417 |
PARP10-15 inhibitor 8l
PARP10 inhibitor
|
PARP10-15 inhibitor 8l (PARP10/15-IN-1) is a potent, dual inhibitor of mono-ADP-ribosyltransferases PARP10 and PARP15 with IC50 of 160 nM and 370 nM respectively, inactive against the other mono-ARTs, PARP12 and PARP16. |
| PC-25416 |
PARP10-15 inhibitor 8h
PARP10 inhibitor
|
PARP10-15 inhibitor 8h (PARP10/15-IN-2) is a potent, dual inhibitor of mono-ADP-ribosyltransferases PARP10 and PARP15 with IC50 of 150 nM and 370 nM respectively, inactive against the other mono-ARTs, PARP12 and PARP16. |
