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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-A-966492
A-966492

Chemical Structure : A-966492

CAS No.: 934162-61-5

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A-966492 (A966492;A 966492)

货号: PC-42678Not For Human Use, Lab Use Only.

A-966492 (A966492) is a highly potent and efficacious PARP inhibitor with Ki/EC50 of 1 nM/1 nM for PARP-1.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3480 In stock
50 mg ￥5580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A-966492 (A966492) is a highly potent and efficacious PARP inhibitor with Ki/EC50 of 1 nM/1 nM for PARP-1, Ki of 1.5 nM for PARP-2.
A-966492 exhibits orally bioavailable across multiple species, crosses the blood-brain barrier, and appears to distribute into tumor tissue.
A-966492 demonstrates good in vivo efficacy in a B16F10 subcutaneous murine melanoma model.

物理化学性质&存储条件

分子量 324.3522
分子式 C18H17FN4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Benzimidazole-7-carboxamide, 2-[2-fluoro-4-[(2S)-2-pyrrolidinyl]phenyl]-

参考文献

1. Penning TD, et al. J Med Chem. 2010 Apr 22;53(8):3142-53.

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