| Cat. No. |
Product Name |
Information |
| PC-42837 |
INO-1001
PARP inhibitor
|
INO-1001 is a potent, selective poly(ADP-ribose) polymerase (PARP). |
| PC-42830 |
BSI-201
PARP1 inhibitor
|
BSI-201 (Iniparib, NSC 746045, IND-71677, SAR240550) is a potent, small molecule PARP1 inhibitor with strong anti-neoplastic effect, demonstrates the potential treatment of breast cancer. |
| PC-62699 |
AZ9482
PARP inhibitor
|
AZ9482 is a potent PARP inhibitor with IC50 of 1/1/46/9/160/640 nM for PAPR1/PARP2/PARP3/TNKS1/TNKS2/PAPR6 respectively. |
| PC-62698 |
AZ0108
PARP inhibitor
|
AZ0108 is an orally bioavailable phthalazinone PARP inhibitor with enzyme IC50 of <30/<30/83 nM for PARP1/2/6 respectively. |
| PC-62410 |
Gallotannin
PARG inhibitor
|
Gallotannin (Tannic acid, Gallotannic acid) is a potent PARG (poly(ADP-ribose) glycohydrolase) inhibitor that produces significant reductions in H2O2-induced cell death in cultured murine astrocytes. |
| PC-61950 |
Simmiparib
PARP1/2 inhibitor
|
Simmiparib is a novel potent, orally active PARP1/2 inhibitor with IC50 of 1.75/0.22 nM, inhibits PARP1 >90-fold more potently than the other PARPs (PARP3, TNKS1, TNKS2). |
| PC-61949 |
Mefuparib hydrochloride
PARP1/2 inhibitor
|
Mefuparib hydrochloride is a potent, highly selective, competitive PARP1/2 inhibitor with IC50 of 3.2/1.9 nM, respectively. |
| PC-61158 |
PARP14 inhibitor H10
PARP14 inhibitor
|
PARP14 inhibitor H10 (H10) is a potent, selective, cell-active PARP14 inhibitor with IC50 of 490 nM, with good selectivity over other PARPs (24-fold and 18-fold over PARP1 and TNKS1, respectively). |
| PC-60483 |
Pamiparib
PARP1/2 inhibitor
|
Pamiparib (BGB-290, BGB290) is a highly potent, selective and brain penetrant PARP1/2 inhibitor with IC50 of 0.9 nM and 0.5 nM for PARP1 and PARP2, respectively. |
| PC-60367 |
TNKS-IN-41
Tankyrase inhibitor
|
TNKS-IN-41 is a highly potent and selective tankyrase inhibitor with pIC50 of 8.5 and 8.1 for TNKS1 and TNKS2, respectively. |
| PC-60021 |
GeA-69
PARP14 inhibitor
|
GeA-69 (GeA69) is a potent, selective, allosteric, cell-active PARP14 macrodomain 2 (MD2) inhibitor with Kd of 0.86 uM in ITC assays. |
| PC-42680 |
Rucaparib
PARP inhibitor
|
Rucaparib (AG014699, PF-01367338) is a potent inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains. |
