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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-Gallotannin
Gallotannin

Chemical Structure : Gallotannin

CAS No.: 5424-20-4

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Gallotannin (Tannic acid, Gallotannic acid, Chinese gallotannin)

货号: PC-62410Not For Human Use, Lab Use Only.

Gallotannin (Tannic acid, Gallotannic acid) is a potent PARG (poly(ADP-ribose) glycohydrolase) inhibitor that produces significant reductions in H2O2-induced cell death in cultured murine astrocytes.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Gallotannin (Tannic acid, Gallotannic acid) is a potent PARG (poly(ADP-ribose) glycohydrolase) inhibitor that produces significant reductions in H2O2-induced cell death in cultured murine astrocytes.
Gallotannin (Tannic acid, Tannin) prevents PARP1-mediated cell death by slowing the turnover of poly(ADP-ribose) and thus slowing NAD(+) consumption.
Gallotannin (Tannic acid, Tannin) increases endogenous DNA damage, stalls replication forks and increases homologous recombination.

物理化学性质&存储条件

分子量 1701.2
分子式 C76H52O46
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

[2,3-dihydroxy-5-[[(2R,3R,4S,5R,6S)-3,4,5,6-tetrakis[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy]oxan-2-yl]methoxycarbonyl]phenyl] 3,4,5-trihydroxybenzoate

参考文献

1. Ying W, et al. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12227-32.

2. Ying W, et al. Neuroreport. 2000 May 15;11(7):1385-8.

3. Fathers C, et al. Cell Cycle. 2012 Mar 1;11(5):990-7.

4. Formentini L, et al. Br J Pharmacol. 2008 Dec;155(8):1235-49.

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