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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-AZ6102
AZ6102

Chemical Structure : AZ6102

CAS No.: 1645286-75-4

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AZ6102 (AZ 6102;AZ-6102)

货号: PC-43304Not For Human Use, Lab Use Only.

AZ6102 is a potent, selective inhibitor of tankyrase TNKS1/2 with IC50 of 3/1 nM, displays >100-fold selectivity against other PARP family enzymes (PARP1/2/6).

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3480 In stock
100 mg ￥5480 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AZ6102 is a potent, selective inhibitor of tankyrase TNKS1/2 with IC50 of 3/1 nM, displays >100-fold selectivity against other PARP family enzymes (PARP1/2/6).
AZ6102 potently inhibits Wnt pathway in DLD-1 cells with IC50 of 5 nM.
AZ6102 AZ6102 is a probe compound to explore the in vivo effects of TNKS1/2 inhibition on normal tissue and tumor xenografts.

物理化学性质&存储条件

分子量 428.5294
分子式 C25H28N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-[4-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-,rel-

参考文献

1. Johannes JW, et al. ACS Med Chem Lett. 2015 Jan 13;6(3):254-9.

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