Chemical Structure : Veliparib
CAS No.: 912444-00-9
货号: PC-42349Not For Human Use, Lab Use Only.
Veliparib (ABT-888) is a potent, BBB penetrant, and orally active PARP inhibitor with IC50 of 5.2 and 2.9 nM for PARP-1 and PARP-2, respectively.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | ¥780 | In stock | |
25 mg | ¥1280 | In stock | |
50 mg | ¥1980 | In stock | |
100 mg | ¥2980 | In stock | |
250 mg | Get quote |
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Veliparib (ABT-888) is a potent, BBB penetrant, and orally active PARP inhibitor with IC50 of 5.2 and 2.9 nM for PARP-1 and PARP-2, respectively.
Veliparib (ABT-888) displays no activity against SIRT2 and selective biochemical profile in a panel of 74 receptor-binding assays.
Veliparib (ABT-888) strongly potentiates temozolomide in the B16F10 s.c. murine melanoma model, also potentiates temozolomide, platinums, cyclophosphamide, and radiation in syngeneic and xenograft tumor models.
分子量 | 244.2923 | |
分子式 | C13H16N4O | |
外观性状 | Solid | |
储存条件 |
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Solubility |
DMSO: ≥ 29 mg/mL |
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Chemical Name/SMILES |
1H-Benzimidazole-7-carboxamide, 2-[(2R)-2-methyl-2-pyrrolidinyl]- |
1. Donawho CK, et al. Clin Cancer Res. 2007 May 1;13(9):2728-37.
2. Albert JM, et al. Clin Cancer Res. 2007 May 15;13(10):3033-42.
3. Liu X, et al. Mol Cancer Res. 2008 Oct;6(10):1621-9.
4. Palma JP, et al. Anticancer Res. 2008 Sep-Oct;28(5A):2625-35.
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