AZ0108 |CAS:1825345-52-5 Probechem Biochemicals

Chemical Structure : AZ0108

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AZ0108 (AZ-0108)

货号: PC-62698Not For Human Use, Lab Use Only.

AZ0108 is an orally bioavailable phthalazinone PARP inhibitor with enzyme IC50 of <30/<30/83 nM for PARP1/2/6 respectively.

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生物&药学活性

AZ0108 is an orally bioavailable phthalazinone PARP inhibitor with enzyme IC50 of <30/<30/83 nM for PARP1/2/6 respectively.
AZ0108 displays >100-fold selectivity against PARP3/TNKS1/TNKS2 (IC50=2.8/3.2/>3 uM).
AZ0108 blocks centrosome clustering in HeLa cell with IC50 of 83 nM.
AZ0108 has been utilized as in vitro tool and in vivo probe to investigate the bio- logical consequences of inhibiting centrosome clustering through PARP enzymes.

物理化学性质&存储条件

分子量	500.458
分子式	1825345-52-5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-((3-(3-(1,1-difluoroethyl)-6-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)phenyl)difluoromethyl)phthalazin-1(2H)-one

参考文献

1. Johannes JW, et al. Bioorg Med Chem Lett. 2015 Dec 15;25(24):5743-7.

AZ0108 (AZ-0108)

生物&药学活性

物理化学性质&存储条件

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AZ0108 (AZ-0108)

生物&药学活性

物理化学性质&存储条件

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