AG14361 |CAS:328543-09-5 Probechem Biochemicals

Chemical Structure : AG14361

CAS No.: 328543-09-5

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AG14361 (AG 14361;AG-14361)

货号: PC-42846Not For Human Use, Lab Use Only.

AG14361 is a potent, specific and competitive inhibitor of PARP-1 with Ki of 5.8 nM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

AG14361 is a potent, specific and competitive inhibitor of PARP-1 with Ki of 5.8 nM。
AG14361 shows potent amplification of the cytotoxic effects of temozolomide (TM) and topotecan (TP) against A549 cells, inhibits LoVo Cell Line with GI50 of 11.2 uM alone。
AG14361 increases the delay of LoVo xenograft growth induced by irinotecan, x-irradiation, or temozolomide by two- to threefold with nontoxicity, causes complete regression of SW620 xenograft tumors combined with temozolomide.

物理化学性质&存储条件

分子量	320.3883
分子式	C19H20N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	Imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one, 2-[4-[(dimethylamino)methyl]phenyl]-5,6-dihydro-

参考文献

1. Veuger SJ, et al. Cancer Res. 2003 Sep 15;63(18):6008-15.

2. Skalitzky DJ, et al. J Med Chem. 2003 Jan 16;46(2):210-3.

3. Curtin NJ, et al. Clin Cancer Res. 2004 Feb 1;10(3):881-9.

4. Smith LM, et al. Clin Cancer Res. 2005 Dec 1;11(23):8449-57.

AG14361 (AG 14361;AG-14361)

生物&药学活性

物理化学性质&存储条件

参考文献

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AG14361 (AG 14361;AG-14361)

生物&药学活性

物理化学性质&存储条件

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