G007-LK |CAS:1380672-07-0 Probechem Biochemicals

Chemical Structure : G007-LK

CAS No.: 1380672-07-0

加入收藏

G007-LK (G007 LK;G007LK)

货号: PC-43035Not For Human Use, Lab Use Only.

G007-LK is a potent, specific, metabolically stable TNKS1/2 inhibitor with IC50 of 46 nM and 25 nM, respectively.

规格	价格	库存
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg	￥4580	In stock
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

G007-LK is a potent, specific, metabolically stable TNKS1/2 inhibitor with IC50 of 46 nM and 25 nM, respectively.
G007-LK reduces Wnt/β-catenin signaling by preventing poly(ADP-ribosyl)ation-dependent AXIN degradation, thereby promoting β-catenin destabilization.
G007-LK effectively blocks ligand-driven Wnt/β-catenin signaling in cell culture and displays approximately 50% inhibition of APC mutation-driven signaling in most CRC cell lines, inhibits the g of mouse intestinal organoids cultured ex vivo with IC50 of 80 nM.
G007-LK inhibits in vivo tumor growth in a subset of APC-mutant CRC xenograft models.

物理化学性质&存储条件

分子量	529.9576
分子式	C25H16ClN7O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	Benzonitrile, 4-[5-[(1E)-2-[4-(2-chlorophenyl)-5-[5-(methylsulfonyl)-2-pyridinyl]-4H-1,2,4-triazol-3-yl]ethenyl]-1,3,4-oxadiazol-2-yl]-

参考文献

1. Voronkov A, et al. J Med Chem. 2013 Apr 11;56(7):3012-23.

2. Lau T, et al. Cancer Res. 2013 May 15;73(10):3132-44.

G007-LK (G007 LK;G007LK)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

G007-LK (G007 LK;G007LK)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.