PARP14 inhibitor H10 |CAS:2084811-68-5 Probechem Biochemicals

Chemical Structure : PARP14 inhibitor H10

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PARP14 inhibitor H10 (H10)

货号: PC-61158Not For Human Use, Lab Use Only.

PARP14 inhibitor H10 (H10) is a potent, selective, cell-active PARP14 inhibitor with IC50 of 490 nM, with good selectivity over other PARPs (24-fold and 18-fold over PARP1 and TNKS1, respectively).

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生物&药学活性

PARP14 inhibitor H10 (H10) is a potent, selective, cell-active PARP14 inhibitor with IC50 of 490 nM, with good selectivity over other PARPs (24-fold and 18-fold over PARP1 and TNKS1, respectively).
H10 inhibits endogenous PARP1 activities, causes activation of JNK1 phosphorylation and apparent formation of cleaved PARP1 in HepG2 cells at 10 uM.

物理化学性质&存储条件

分子量	557.582
分子式	C24H27N7O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(N-(2-(4-(2-(4-((3-carbamoylphenyl)amino)-4-oxobutanamido)ethyl)-1H-1,2,3-triazol-1-yl)ethyl)sulfamoyl)benzoic acid

参考文献

1. Peng B, et al. Angew Chem Int Ed Engl. 2017 Jan 2;56(1):248-253.

PARP14 inhibitor H10 (H10)

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物理化学性质&存储条件

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PARP14 inhibitor H10 (H10)

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物理化学性质&存储条件

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