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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-MN-64
MN-64

Chemical Structure : MN-64

CAS No.: 92831-11-3

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MN-64 (TNKS1 inhibitor MN64)

货号: PC-45620Not For Human Use, Lab Use Only.

MN-64 is a potent and selective inhibitor of Tankyrase 1 (TNKS1) with IC50 of 6 nM.

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10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥1980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MN-64 is a potent and selective inhibitor of Tankyrase 1 (TNKS1) with IC50 of 6 nM.
MN-64 displays 12-fold selectivity over TNKS2 (IC50=72 nM) and no signigicant inhibitory activity on PARP1 and PARP2 (IC50>10 uM).
MN-64 show an Wnt-signaling IC50 of 200 nM in the STF assay.

物理化学性质&存储条件

分子量 264.3185
分子式 C18H16O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4H-1-Benzopyran-4-one, 2-[4-(1-methylethyl)phenyl]-

参考文献

1. Narwal M, et al. J Med Chem. 2013 Oct 24;56(20):7880-9.

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