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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-GeA-69
GeA-69

Chemical Structure : GeA-69

CAS No.: 2143475-98-1

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GeA-69 (GeA69)

货号: PC-60021Not For Human Use, Lab Use Only.

GeA-69 (GeA69) is a potent, selective, allosteric, cell-active PARP14 macrodomain 2 (MD2) inhibitor with Kd of 0.86 uM in ITC assays.

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10 mg ￥480 In stock
25 mg ￥880 In stock
50 mg ￥1280 In stock
100 mg ￥1980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GeA-69 (GeA69) is a potent, selective, allosteric, cell-active PARP14 macrodomain 2 (MD2) inhibitor with Kd of 0.86 uM in ITC assays.
GeA-69 displays high selectivity over other human macrodomains.
GeA-69 engages PARP14 MD2 in intact cells and prevents its localization to sites of DNA damage.

物理化学性质&存储条件

分子量 300.361
分子式 C20H16N2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-(9H-carbazol-1-yl)phenyl)acetamide

参考文献

1. Schuller M, et al. ACS Chem Biol. 2017 Nov 17;12(11):2866-2874.

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