Rucaparib (AG014699, PF-01367338) | PARP inhibitor | Probechem Biochemicals

Chemical Structure : Rucaparib

CAS No.: 283173-50-2

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Rucaparib (AG014699, PF-01367338, AG-014699)

货号: PC-42680Not For Human Use, Lab Use Only.

Rucaparib (AG014699, PF-01367338) is a potent inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
50 mg	￥1980	In stock
100 mg	￥2980	In stock
250 mg		Get quote

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生物&药学活性

Rucaparib (AG014699, PF-01367338) is a potent inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains.
Rucaparib (AG014699, PF-01367338) inhibits PARP-1 activity by 97.1% at a concentration of 1 μM in permeabilised D283Med cells.
Rucaparib (AG014699, PF-01367338) enhances the antitumor activity of temozolomide and indicates complete and sustained tumor regression in NB1691 and SHSY5Y xenografts.

物理化学性质&存储条件

分子量	323.3641
分子式	C19H18FN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one, 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-

参考文献

1. Thomas HD, et al. Mol Cancer Ther, 2007, 6(3), 945-956.

2. Daniel RA, et al. Clin Cancer Res, 2009, 15(4), 1241-1249.

3. Daniel RA, et al. Br J Cancer, 2010, 103(10), 1588-1596.

Rucaparib (AG014699, PF-01367338, AG-014699)

生物&药学活性

物理化学性质&存储条件

参考文献

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Rucaparib (AG014699, PF-01367338, AG-014699)

生物&药学活性

物理化学性质&存储条件

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