Olaparib (AZD2281, KU-0059436) | PARP inhibitor | Probechem Biochemicals

Chemical Structure : Olaparib

CAS No.: 763113-22-0

加入收藏

Olaparib (AZD2281, KU-0059436, KU0059436, AZD-2281)

货号: PC-42410Not For Human Use, Lab Use Only.

Olaparib (AZD2281, KU-0059436) is a potent, specific, and orally active PARP inhibitor with IC50 of 5 and 1 nM for PARP1 and PARP2, respectively.

规格	价格	库存
50 mg	￥980	In stock
100 mg	￥1580	In stock
250 mg	￥2580	In stock
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Olaparib (AZD2281, KU-0059436) is a potent, specific, and orally active PARP inhibitor with IC50 of 5 and 1 nM for PARP1 and PARP2, respectively.
Olaparib (AZD2281, KU-0059436) displays 300-fold selectivity over tankyrase (TNKS-1 IC50=1.5 uM).
Olaparib (AZD2281, KU-0059436) shows standalone activity against BRCA1-deficient breast cancer cell lines.
Olaparib (AZD2281, KU-0059436) regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin.

物理化学性质&存储条件

分子量	434.4628
分子式	C24H23FN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 29 mg/mL
Chemical Name/SMILES	1(2H)-Phthalazinone, 4-[[3-[[4-(cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-

参考文献

1. Menear KA, et al. J Med Chem. 2008 Oct 23;51(20):6581-91.

2. Evers B, et al. Clin Cancer Res. 2008 Jun 15;14(12):3916-25.

3. Rottenberg S, et al. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17079-84.

4. Hay T, et al. Cancer Res. 2009 May 1;69(9):3850-5.

Olaparib (AZD2281, KU-0059436, KU0059436, AZD-2281)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Olaparib (AZD2281, KU-0059436, KU0059436, AZD-2281)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.