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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-Rucaparib phosphate
Rucaparib phosphate

Chemical Structure : Rucaparib phosphate

CAS No.: 459868-92-9

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Rucaparib phosphate (AG014699 phosphate;PF01367338 phosphate;AG 014699 phosphate;PF 01367338 phosphate;AG-014699 phosphate;PF-01367338 phosphate)

货号: PC-42679Not For Human Use, Lab Use Only.

Rucaparib (AG014699, PF 01367338) phosphate is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains.

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25 mg ￥1580 In stock
50 mg ￥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Rucaparib (AG014699, PF 01367338) phosphate is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains.
Rucaparib  inhibits PARP-1 activity by 97.1% at a concentration of 1 μM in permeabilised D283Med cells.
Rucaparib  enhances the antitumor activity of temozolomide and indicates complete and sustained tumor regression in NB1691 and SHSY5Y xenografts.

物理化学性质&存储条件

分子量 421.3593
分子式 C19H21FN3O5P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 33 mg/mL
Chemical Name/SMILES

6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one, 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-, phosphate (1:1)

参考文献

1. Thomas HD, et al. Mol Cancer Ther, 2007, 6(3), 945-956.

2. Daniel RA, et al. Clin Cancer Res, 2009, 15(4), 1241-1249.

3. Daniel RA, et al. Br J Cancer, 2010, 103(10), 1588-1596.

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