Mefuparib hydrochloride |CAS:1449746-00-2 Probechem Biochemicals

Chemical Structure : Mefuparib hydrochloride

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Mefuparib hydrochloride

货号: PC-61949Not For Human Use, Lab Use Only.

Mefuparib hydrochloride is a potent, highly selective, competitive PARP1/2 inhibitor with IC50 of 3.2/1.9 nM, respectively.

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100 mg		Get quote

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生物&药学活性

Mefuparib hydrochloride is a potent, highly selective, competitive PARP1/2 inhibitor with IC50 of 3.2/1.9 nM, respectively.
Mefuparib displays >406-fold over other major nuclear PARPs including PARP3, TNKS1, TNKS2 and PARP6.
Mefuparib reduces poly(ADP-ribose) formation, enhances γH2AX levels, induces G2/M arrest and subsequent apoptosis in homologous recombination repair (HR)-deficient cells.
Mefuparib shows potent in vitro and in vivo proliferation and growth inhibition against HR-deficient cancer cells and synergistic sensitization of HR-proficient xenografts to the anticancer drug temozolomide.

物理化学性质&存储条件

分子量	334.775
分子式	C17H16ClFN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-fluoro-2-(4-((methylamino)methyl)phenyl)benzofuran-7-carboxamide hydrochloride

参考文献

1. He JX, et al. Oncotarget. 2017 Jan 17;8(3):4156-4168.