| Cat. No. |
Product Name |
Information |
| PC-62978 |
L-α-Hydroxyglutaric acid disodium
Dioxygenase inhibitor
|
L-α-Hydroxyglutaric acid disodium (L-2-Hydroxyglutarate, L-2-HG) competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases. |
| PC-62871 |
Bizine
LSD1 inhibitor
|
Bizine is a phenelzine analog that inhibits LSD1 with Ki of 59 nM, displays 23-fold, 63-fold, and >100-fold selectivity for LSD-1 over MAOA, MAOB, and LSD2 respectively. |
| PC-62840 |
LSD1-IN-11p
LSD1 inhibitor
|
LSD1-IN-11p is a potent, reversible LSD1 inhibitor with IC50/Kd of 79/21 nM. |
| PC-62837 |
KDM4D-IN-10r
KDM4D inhibitor
|
KDM4D-IN-10r is a potent, selective histone lysine demethylase 4D (KDM4D) inhibitor with IC50 of 0.41 uM. |
| PC-62835 |
KDM5A-IN-50
KDM5 inhibitor
|
KDM5A-IN-50 is a potent, selective, and orally bioavailable pan KDM5 enzyme inhibitor with biochemical IC50 of 45/56/55 nM for KDM5A/KDM5B/KDM5C respectively. |
| PC-62327 |
AS8351
KDM5B inhibitor
|
AS8351 (NS 51355) is a small molecule that induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR 99021, A83-01, BIX 01294, SC1, Y-27632, OAC2, SU 16f and JNJ 10198409, inhibits lysine demethylase 5B (KDM5B). |
| PC-62294 |
KDM5-C49
KDM5 inhibitor
|
KDM5-C49 is a potent, selective KDM5 inhibitor with IC50 of 25, 30 and 59 nM for KDM5A, B and C, respectively. |
| PC-62293 |
KDM5-C70
KDM5 inhibitor
|
KDM5-C70 (GS-5801) is a cell-permeable derivative of KDM5-C49 (GS-080), potent, selective and cell permeable KDM5 inhibitor with IC50 of 0.3, 0.3 and 0.58 uM for KDM5A, B and C, respectively. |
| PC-62292 |
GSK467
KDM5 inhibitor
|
GSK467 (GSK-467) is a potent, selective KDM5 inhibitor with Ki of 10 nM, shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other JmJ family members. |
| PC-61956 |
NCD-25
LSD1 inhibitor
|
NCD-25 is a novel potent, selective LSD1 inhibitor with IC50 of 0.48 uM, exerts highly selective inhibitory activity on LSD1 but no other enzymes, such as MAO.. |
| PC-61955 |
NCD-38
LSD1 inhibitor
|
NCD-38 is a novel potent, selective LSD1 inhibitor with IC50 of 0.59 uM, exerts highly selective inhibitory activity on LSD1 but no other enzymes, such as MAO (IC50>100 uM). |
| PC-61816 |
E67-2
KDM7A inhibitor
|
E67-2 is a potent and selective inhibitor of H3K9 Jumonji demethylase KIAA1718 (KDM7A) with IC50 of 3.4 uM. |
