LSD1 inhibitor 24 |CAS:1853269-07-4 Probechem Biochemicals

Chemical Structure : LSD1 inhibitor 24

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LSD1 inhibitor 24

货号: PC-35794Not For Human Use, Lab Use Only.

LSD1 inhibitor 24 is a novel potent, selective lysine-specific demethylase 1 (LSD1) inhibitor with IC50 of 1 nM, induces CD11b expression in THP-1 cells with EC50 of 8 nM.

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50 mg		Get quote
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1 g		Get quote

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生物&药学活性

LSD1 inhibitor 24 is a novel potent, selective lysine-specific demethylase 1 (LSD1) inhibitor with IC50 of 1 nM, induces CD11b expression in THP-1 cells with EC50 of 8 nM.
LSD1 inhibitor 24 demonstrates attenuating the hERG inhibition and improving oral bioavailability.

物理化学性质&存储条件

分子量	505.982
分子式	C26H25ClFN7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-(1-(3-chloro-2-methyl-2H-indazol-5-yl)-5-methyl-4-(3-(methylamino)piperidine-1-carbonyl)-1H-imidazol-2-yl)-2-fluorobenzonitrile

参考文献

1. Nie Z, et al. Bioorg Med Chem Lett. 2018 Nov 3. pii: S0960-894X(18)30855-2.