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首页-小分子抑制剂&激动剂-Epigenetics-Histone Demethylase-ORY-1001
ORY-1001

Chemical Structure : ORY-1001

CAS No.: 1431326-61-2

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ORY-1001 (Iadademstat;RG 6016;RG6016;RG-6016;ORY1001;ORY 1001)

货号: PC-43206Not For Human Use, Lab Use Only.

ORY-1001 (RG-6016) is a highly potent, selective inhibitor of lysine-specific demethylase KDM1A (LSD1) with IC50 of 18 nM, displays high selectivity for KDM1A over other FAD-containing monoamine oxidases.

规格 价格 库存 数量
5 mg ￥1180 In stock
10 mg ￥1880 In stock
25 mg ￥3280 In stock
50 mg ￥5480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ORY-1001 (RG-6016, Iadademstat) is a highly potent, selective inhibitor of lysine-specific demethylase KDM1A (LSD1) with IC50 of 18 nM, displays high selectivity for KDM1A over other FAD-containing monoamine oxidases.
ORY-1001 (RG-6016, Iadademstat)  exhibits low nanomolar cellular activity (EC50 < 1 nM) in the THP1 differentiation assay and induces the CD11b marker within 6 hr of treatment in FACS based differentiation assay in THP1 cell line.
ORY-1001 (RG-6016, Iadademstat)  induces H3K4me2 accumulation on KDM1A target genes, blast differentiation, and reduction of leukemic stem cell capacity in AML.
ORY-1001 (RG-6016, Iadademstat)  exhibits potent synergy with standard-of-care drugs and selective epigenetic inhibitors, reduces growth of AML xenograft models.

物理化学性质&存储条件

分子量 303.2704
分子式 C15H24Cl2N2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: < 6.8 mg/mL
Chemical Name/SMILES

trans-N1-(2-Phenylcyclopropyl)cyclohexane-1,4-diamine dihydrochloride

参考文献

1. Maes T, et al. Cancer Cell. 2018 Mar 12;33(3):495-511.e12.

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