ML324 |CAS:1222800-79-4 Probechem Biochemicals

Chemical Structure : ML324

CAS No.: 1222800-79-4

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ML324 (ML-324)

货号: PC-43163Not For Human Use, Lab Use Only.

ML324 is a potent, selective JMJD2 demethylase (KDM4) inhibitor with IC50 of 920 nM for JMJD2E, shows no activity against LSD1 (>100-fold selectivity).

规格	价格	库存
25 mg	￥1680	In stock
50 mg	￥2280	In stock
100 mg	￥3680	In stock
250 mg	￥6580	In stock
1 g		Get quote

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生物&药学活性

ML324 is a potent, selective JMJD2 demethylase (KDM4) inhibitor with IC50 of 920 nM for JMJD2E, shows no activity against LSD1 (>100-fold selectivity).
ML324 causes depression-like phenotype even in absence of stress exposure, which is associated with an increase in transcriptionally repressive epigenetic marks H3K9me2/me3 in nucleus accumbens (NAc).
ML324 blocks TNF-α-mediated neutrophil adhesion, reduces TNF-α-induced ICAM1 protein expression in cerebral microvessels.

物理化学性质&存储条件

分子量	349.4262
分子式	C21H23N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	Benzamide, N-[3-(dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)-

参考文献

1. Rai G, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Pathak SS, et al. Neuropsychopharmacology. 2017 Mar;42(4):854-863.

3. Choi JY, et al. Sci Rep. 2017 Mar 22;7:45005.

4. Ishiguro K, et al. Clin Immunol. 2017 Jul;180:120-127.

ML324 (ML-324)

生物&药学活性

物理化学性质&存储条件

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ML324 (ML-324)

生物&药学活性

物理化学性质&存储条件

参考文献

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