| Cat. No. |
Product Name |
Information |
| PC-20353 |
CBA-1
KDM3A inhibitor
|
CBA-1 is a small molecule inhibitor of Wnt signaling, specifically targets Jumonji (JmjC) domain-containing demethylase KDM3A with IC50 of 3.9 uM. |
| PC-20352 |
EPZ020809
KDM4C inhibitor
|
EPZ020809 is a potent, specific KDM4C inhibitor with Ki of 31 nM, binds KDM4C in a 2-OG-competitive fashion. |
| PC-20255 |
Bomedemstat
LSD1 inhibitor
|
Bomedemstat (IMG-7289) is a potent, selective, irreversible and orally active LSD1 (KDM1A) inhibitor, increases H3K4 and H3K9 methylation. |
| PC-49244 |
iJMJD6
JMJD6 inhibitor
|
iJMJD6 is a potent, specific small-molecule JMJD6 inhibitor that specifically binds to JMJD6 (ITC Kd=3.83 uM) and competes with α-KG and the substrate for binding, inhibits the demethylase activity of JMJD6 with IC50 of 149.6 nM. |
| PC-49236 |
FTO-43
FTO inhibitor
|
FTO-43 (FTO-43 N) is a potent, selective inhibitor of the m6A demethylase fat mass- and obesity-associated protein (FTO) with IC50 of 1.0 uM, no significant acitivity against the homologous m6A RNA demethylase ALKBH5 (IC50>40 uM). |
| PC-38672 |
Pulrodemstat benzenesulfonat
LSD1 inhibitor
|
Pulrodemstat (CC-90011) is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with biochemical IC50 of 0.3 nM. |
| PC-38671 |
Pulrodemstat
LSD1 inhibitor
|
Pulrodemstat (CC-90011) is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with biochemical IC50 of 0.3 nM. |
| PC-38508 |
GSK-J1
KDM6A/6B inhibitor
|
GSK-J1 is a potent, selective inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 28 nM and 53 nM, respectively. |
| PC-72834 |
JIB-04
Jumonji KDM inhibitor
|
JIB-04 is a pan-Jumonji histone demethylase inhibitor (IC50=230-1100 nM) with epigenetic activity, also potently inhibits SARS-CoV-2 replication in Vero E6 cells with EC50 of 695 nM. |
| PC-72453 |
KDOBA67
KDM6A/B inhibitor
|
KDOBA67 is a novel cell-permeable inhibitor of H3K27 lysine demethylase KDM6A/B, inhibits TBXT expression chordoma cell lines. |
| PC-72386 |
MO-I-500
FTO inhibitor
|
MO-I-500 is a pharmacological inhibitor of FTO, inhibits purified FTO demethylase catalyzing demethylation with IC50 of 8.7 uM. |
| PC-72385 |
FTO inhibitor CS1
FTO inhibitor
|
FTO inhibitor CS1 (Bisantrene, NSC 337766) is a potent, selective small-molecule inhibitor of m6A demethylase FTO, inhibits m6A demethylation with IC50 of 142.6 nM in vitro (cell-free) assays. |
