GSK-J4 | KDM6A/6B inhibitor | Probechem Biochemicals

Chemical Structure : GSK-J4

CAS No.: 1373423-53-0

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GSK-J4 (GSK-J4 hydrochloride)

货号: PC-21211Not For Human Use, Lab Use Only.

GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively, GSK-J4 s a cell permeable prodrug of GSK-J1.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2280	In stock
100 mg		Get quote

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生物&药学活性

GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively, GSK-J4 s a cell permeable prodrug of GSK-J1.
GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with IC50 of 9 uM.
GSK-J4 prevents the JMJD3-induced loss of nuclear H3K27me3 immunostaining in Flag-JMJD3-transfected HeLa cells.
GSK-J4 inhibits JMJD3 expression that is induced by TGF-β1, inhibits H3K4 demethylation at Xist, Nodal, and HoxC13 in female embryonic stem cells.
GSK-J4 attenuates the development of kidney disease in diabetic mice.

物理化学性质&存储条件

分子量	453.97
分子式	C24H28ClN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate hydrochloride

参考文献

1. Kruidenier L, et al. Nature. 2012 Aug 16;488(7411):404-8.

2. Majumder S, et al. J Clin Invest. 2018 Jan 2;128(1):483-499.

3. Donas C, et al. J Autoimmun. 2016 Dec;75:105-117.

GSK-J4 (GSK-J4 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK-J4 (GSK-J4 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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