ALKBH1 inhibitor 13h

Chemical Structure : ALKBH1 inhibitor 13h

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货号: PC-21915Not For Human Use, Lab Use Only.

ALKBH1 inhibit 13h is a potent, isoform selective, and cell-active DNA 6mA demethylase ALKBH1 inhibitor with 26 nM and 1.39 uM in FP and enzyme activity assay, respectively.

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50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

ALKBH1 inhibit 13h is a potent, isoform selective, and cell-active DNA 6mA demethylase ALKBH1 inhibitor with 26 nM and 1.39 uM in FP and enzyme activity assay, respectively.
ALKBH1 inhibit 13h shows high binding affinity with ITC KD value of 112 nM.
ALKBH1 inhibit 13h engages ALKBH1 and modulates the 6mA levels in cells.

物理化学性质&存储条件

分子量	380.28
分子式	C16H11F3N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-((3-(trifluoromethoxy)benzyl)oxy)pyrimidin-2-yl)-1H-pyrazole-4-carboxylic acid

参考文献

1. Liang Xiong, et al. J Am Chem Soc. 2024 Mar 4. doi: 10.1021/jacs.4c00194.