JMJD5 inhibitor 19j | JMJD5 inhibitor | Probechem Biochemicals

Chemical Structure : JMJD5 inhibitor 19j

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JMJD5 inhibitor 19j (KDM8 inhibitor)

货号: PC-21085Not For Human Use, Lab Use Only.

JMJD5 inhibitor 19j is a potent selective small molecule inhibitor of 2OG-dependent oxygenase JMJD5 (KDM8), shows high selectivity over other human 2OG oxygenases.

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生物&药学活性

JMJD5 inhibitor 19j is a potent selective small molecule inhibitor of 2OG-dependent oxygenase JMJD5 (KDM8), shows high selectivity over other human 2OG oxygenases.
JMJD5 inhibitor 19j does not significantly affect U2OS bone osteosarcoma or PC3 prostate adenocarcinoma cells (IC50=10 uM), substantially reduces the growth of A549 lung adenocarcinoma cells with IC50 of 2.1 uM.
JMJD5 inhibitor 19j (1 uM, 24h) significantly induced both micronuclei and 53BP1 bodies in A549 cells.
JMJD5 inhibitor 19j (1 uM, 24h)caused a reduction in G1-phase cells, with a corresponding increase in S- and G2/M-phase cells in A549 cells.

物理化学性质&存储条件

分子量	340.38
分子式	C19H20N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Dimethyl 5-((2-cyclopropylbenzyl)amino)pyridine-2,4-dicarboxylate

参考文献

1. Lennart Brewitz, et al. J Med Chem. 2023 Aug 10;66(15):10849-10865.

JMJD5 inhibitor 19j (KDM8 inhibitor)

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物理化学性质&存储条件

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JMJD5 inhibitor 19j (KDM8 inhibitor)

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