SP2509 |CAS:1423715-09-6 Probechem Biochemicals

Chemical Structure : SP2509

CAS No.: 1423715-09-6

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SP2509 (SP-2509)

货号: PC-43122Not For Human Use, Lab Use Only.

SP2509 is a potent, selective histone demethylase LSD1 (KDM1A) inhibitor with IC50 of 13 nM, shows no activity against MAOA, MAOB, LDH and glucose oxidase.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

SP2509 is a potent, selective histone demethylase LSD1 (KDM1A) inhibitor with IC50 of 13 nM, shows no activity against MAOA, MAOB, LDH and glucose oxidase.
SP2509 inhibits the colony growth of OCI-AML3 significantly more than of the other AML cell-types, induces more apoptosis of AML cells expressing mutant NPM1 than mixed-lineage leukemia fusion oncoproteins.
SP2509 significantly improves the survival of immune-depleted mice model of AML.
SP2509 is synergistically lethal against cultured and primary AML blasts combined with panobinostat.

物理化学性质&存储条件

分子量	437.8972
分子式	C19H20ClN3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	(E)-N'-(1-(5-Chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide

参考文献

1. Fiskus W, et al. Leukemia. 2014 Nov;28(11):2155-64.

2. Sonnemann J, et al. Br J Haematol. 2017 Dec 3. doi: 10.1111/bjh.14983.

3. Sehrawat A, et al. Proc Natl Acad Sci U S A. 2018 Mar 26. pii: 201719168.

4. Khanal T, et al. Sci Rep. 2017 Sep 6;7(1):10662.

SP2509 (SP-2509)

生物&药学活性

物理化学性质&存储条件

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SP2509 (SP-2509)

生物&药学活性

物理化学性质&存储条件

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